FC

Crosstalk between human <fc>DC</fc> subsets promotes antibacterial activity and <fc>CD</fc>8^#x0002B; <fc>T</fc>#x02010;cell stimulation in response to bacille <fc>C</fc>almette#x02010;<fc>G</fc>u#x000E9;rin

To date, little is known about the unique contributions of specialized human DC subsets to protection against tuberculosis (TB). Here, we focus on the role of human plasmacytoid (p)DCs and myeloid (m)DCs in the immune response to the TB vaccine bacille CalmetteGuérin (BCG). Ex vivo DC subsets from human peripheral blood were purified and infected with BCG expressing GFP to distinguish between i...

Exposure to inflammatory cytokines selectively limits <fc>GM</fc><fc>CSF</fc> production by induced T regulatory cells

Interest in manipulating the immunosuppressive powers of Foxp3-expressing T regulatory cells as an immunotherapy has been tempered by their reported ability to produce proinflammatory cytokines when manipulated in vitro, or in vivo. Understanding processes that can limit this potentially deleterious effect of Treg cells in a therapeutic setting is therefore important. Here, we have studied this...

IgE Enhances Fc

Heartache of fc receptors.

diopathic dilated cardiomypathy (DCM) is characterized y the progressive depression of cardiac function and left entricular dilation in the absence of coronary artery disease. here is evidence to suggest that humoral immunity plays n important role in the pathogenesis of DCM. In particlar, the role of autoantibodies in the pathogenesis of DCM as been emphasized (1). Sera from patients with DCM ...

Therapeutic Fc-Fusion Proteins

This new, comprehensive text published by Wiley Blackwell provides a much needed re-write on the earlier publication of 15 y ago, published just after the approval of the first Fc-fusion protein, etanercept (Enbrel). The field of therapeutic proteins, dominated by antibodies and Fc-fusion proteins, has advanced dramatically over this period, with multiple new structures and successful therapeut...